Effect of Genetic Variation on Facial Growth during Puberty
نویسندگان
چکیده
Objective: Our aim was to determine whether genetic variations in the GHR and IGF1 genes were associated with differences in facial growth rates. Methods: Cervical Vertebral Maturation Stages (CVMS) were evaluated on initial radiographs by 3 clinicians; 182 subjects in CVMS3 (98F/84M) were studied. Subjects were genotyped for rs2972408, rs4130114, rs6180 (GHR) and rs10735380, rs1520220, rs2946834 (IGF1). Initial and final cephalometric radiographs were traced by one clinician. Differences in measurements were annualized over treatment time, and a stepwise multiple regression was performed.Results: Genetic variation in IGF1 rs1520220 was associated with changes in SNA. Changes in S-Go were associated with IGF1 rs1073530 and GHR rs4130114. Variation in GHR rs6180 was related to changes in mandibular length.Conclusions: Genetic variation in GHR/IGF1 explains some variability in facial growth, and aids in our understanding of the portion of growth influenced by growth modification.
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